Radix Rehmanniae Glutinosae Praeparata

Tóm tắt

nan

I. Thông tin về dược liệu

Định danh

• Dược liệu tiếng Việt: Thục Địa - Rễ Củ Đã Chế Biến
• Dược liệu tiếng Trung: ? (?)
• Dược liệu tiếng Anh: ?
• Dược liệu latin thông dụng: Radix Rehmanniae Glutinosae Praeparata
• Dược liệu latin kiểu DĐVN: Radix Rehmanniae Glutinosae Praeparata
• Dược liệu latin kiểu DĐVN: nan
• Dược liệu latin kiểu thông tư: nan
• Bộ phận dùng: Rễ Củ Đã Chế Biến (Radix praeparata)

Mô tả dược liệu

Theo dược điển Việt nam V: Phiến dày hoặc khối không đều. Mặt ngoài bóng. Chất mềm, dai, khó bẻ gãy. Mặt cắt ngang đến nhánh, mịn bỏng. Không mùi, vị ngọt.

Mô tả dược liệu theo thông tư chế biến dược liệu theo phương pháp cổ truyền: nan

Chế biến

Chế biến theo dược điển việt nam V: Cách 1: Lấy Sinh địa đã rửa sạch, cho vào thùng, xếp củ to ở dưới, cù nhỏ ở trên. Cứ 90 kg Sinh địa thêm 10 L rượu. đun đến sôi, tiếp tục đun nhỏ lửa từ 6 h đến 8 h cho đến cạn. Trong khi đun, cứ khoảng 1 h lại lấy nước ở đáy nồi tưới lên các củ cho thâm đều. Sau lấy ra phơi 3 ngày, rồi lại đem nấu lần thứ 2 với nước gừng. Dùng 2 kg Gừng tươi giã nhỏ cho vào nước, khuấy đều, lọc lấy nước, nấu với Sinh địa. Sau đó lại vớt Sinh địa ra phơi, rồi lại nấu. Làm như vậy 5 lần đến 7 lần, đến khi dược liệu có màu đến nhánh.
Cách 2:
Công thức:
Sinh địa                                                           100 kg
Sa nhân                                                           1,5 kg
Gừng tươi                                                        10,0 kg
Rượu (hàm lượng ethanol 22 % đến 25 %)    45,0 L
Lấy sinh địa, loại bỏ đất cắt, rửa sạch, để ráo nước. Lấy gừng tươi, rửa sạch, thái nhỏ hoặc xay ướt. Lấy sa nhân, loại bỏ tạp chất, rửa sạch, đập, giã hoặc xay nhỏ. Cho gừng tươi và sa nhân vào nồi nấu hai vỏ. Thêm nước, đun sôi, điều chỉnh nhiệt độ để sôi âm ỉ trong 1 h, rút dịch chiết sa nhân – gừng để được khoảng 50 L.
Cho sinh địa đã ráo nước vào nồi nấu hai vỏ. Tẩm sinh địa với 1.2 lượng rượu theo công thức (22,5 L) cùng với dịch chiết sa nhân – gừng, ngâm ủ trong 2 h. Nếu lượng dịch sa nhân – gừng, rượu chưa đủ ngập sinh địa thì bổ sung thêm nước sạch (yêu cầu cao hơn mặt sinh địa 2 cm đến 3 em). Tiến hành nấu trong 3 ngày, mỗi ngày đun âm ỉ trong 6 h. Đêm ngừng nấu. Sau mỗi ngày bổ sung thêm nước sôi cho đủ ngập. Đến ngày thứ 4 thì rút dịch nấu, gộp cùng 1/2 lượng rượu còn lại. Sinh địa trong nồi được đảo trộn dưới cho đều. Đổ lượng dịch nấu gộp với rượu ở trên vào nồi và ngâm ủ trong 2 h. Bổ sung nước cho ngập rôi đun âm ỉ tiếp trong 6 h. Đêm ngừng nấu. Ngày thứ 5 tiếp tục nấu và điều chỉnh lượng nước sao cho lượng dịch nấu rút ra ngày hôm sau chi còn khoảng 9 L đến 10 L. Sinh địa được nấu trở nên đen nhánh, có mùi thơm, vị ngọt. Để nguyên hoặc thái lát dày 3 mm đến 4 mm. sấy. Tẩm với dịch còn lại trong quá trình sấy. Quá trinh tẩm – sấy (hoặc phơi nắng) được làm liên tục cho tới khi hết dịch và thục địa thu được trở nên đến, láng bóng, khô, dẻo, thớ dai chắc, sờ không dính tay là được.

Chế biến theo thông tư: nan

II. Thông tin về thực vật

Dược liệu Thục Địa - Rễ Củ Đã Chế Biến từ bộ phận Rễ Củ Đã Chế Biến từ loài Rehmannia glutinosa.

Mô tả thực vật: nan

Tài liệu tham khảo: nan Trong dược điển Việt nam, loài Rehmannia glutinosa được sử dụng làm dược liệu.

Phân loại thực vật của Rehmannia glutinosa

Kingdom: Plantae

Phylum: Tracheophyta

Order: Lamiales

Family: Rehmanniaceae

Genus: Rehmannia

Species: Rehmannia glutinosa

Phân bố trên thế giới: nan, United States of America, China, Sweden, New Zealand, Brazil, Korea, Republic of

Phân bố tại Việt nam: Không có ghi nhận ở Việt Nam

III. Thành phần hóa học

Theo tài liệu của GS. Đỗ Tất Lợi: nan

Theo cơ sở dữ liệu lotus, loài Rehmannia glutinosa đã phân lập và xác định được 228 hoạt chất thuộc về các nhóm Cinnamic acids and derivatives, Naphthopyrans, Pyrans, Carboxylic acids and derivatives, Diazines, Epoxides, Dihydrofurans, Pyrimidine nucleosides, Organooxygen compounds, Indoles and derivatives, Lactones, Prenol lipids, Tannins, Oxanes, Steroids and steroid derivatives, Fatty Acyls, Hydroxy acids and derivatives, Furans, Sphingolipids, Organonitrogen compounds, Heteroaromatic compounds, Oxepanes trong bảng dưới đây.

chemicalTaxonomyClassyfireClass	smiles_count
Carboxylic acids and derivatives	679
Cinnamic acids and derivatives	2744
Diazines	12
Dihydrofurans	18
Epoxides	21
Fatty Acyls	516
Furans	34
Heteroaromatic compounds	52
Hydroxy acids and derivatives	21
Indoles and derivatives	29
Lactones	103
Naphthopyrans	77
Organonitrogen compounds	38
Organooxygen compounds	5692
Oxanes	98
Oxepanes	25
Prenol lipids	7722
Pyrans	44
Pyrimidine nucleosides	46
Sphingolipids	104
Steroids and steroid derivatives	83
Tannins	618

Danh sách chi tiết các hoạt chất như sau:

Nhóm Carboxylic acids and derivatives.

Nhóm Cinnamic acids and derivatives.

Nhóm Diazines.

Nhóm Dihydrofurans.

Nhóm Epoxides.

Nhóm Fatty Acyls.

Nhóm Furans.

Nhóm Heteroaromatic compounds.

Nhóm Hydroxy acids and derivatives.

Nhóm Indoles and derivatives.

Nhóm Lactones.

Nhóm Naphthopyrans.

Nhóm Organonitrogen compounds.

Nhóm Organooxygen compounds.

Nhóm Oxanes.

Nhóm Oxepanes.

Nhóm Prenol lipids.

Nhóm Pyrans.

Nhóm Pyrimidine nucleosides.

Nhóm Sphingolipids.

Nhóm Steroids and steroid derivatives.

Nhóm Tannins.

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IV. Tác dụng dược lý

Theo tài liệu quốc tế: nan

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V. Dược điển Việt Nam V

Soi bột

nan

Vi phẫu

nan

Định tính

Phương pháp sắc ký lớp mỏng (Phụ lục 5.4).
Bản mỏng: Silica gel GF254.
Dung môi khai triển: Ethylacetat – methanol – acid formic (16:0,5:2).
Dung dịch thử: Lấy 1 g dược liệu đã cắt nhỏ, thêm 50 ml methanol (TT) 80 %, lắc siêu âm 30 min, lọc. có dịch lọc trên cách thủy đến cạn, hòa cắn trong 5 ml nước. Lăc với n-butanol đã bão hòa nước (TT) 4 lần. mỗi lần 10 ml. Gộp dịch chiết n-butanol, cô đến cạn. Hòa cắn trong 2 ml methanol (TT) làm dung dịch chấm sắc ký.
Dung dịch đối chiếu: Hòa tan verbascosid chuẩn trong methanol (TT) để được dung dịch có nồng độ khoảng 1 mg/ml. Cách tiến hành: Chấm riêng biệt lên bản mỏng 5 µl mỗi dung dịch trên. Sau khi triển khai, để khô bản mỏng ở nhiệt độ phòng, phun dung dịch 2 -aminoethyl diphenylorinat 1 % trong methanol (TT), sấy bản mỏng ở 105 °C trong 5 min. Quan sát bản mỏng dưới ánh sáng tử ngoại tại bước sóng 366 tim, Trên sắc ký đồ của dung dịch thử phải có vết cùng màu và cùng giá trị Rf với vết chính trên sắc ký đồ của dung dịch đối chiếu.

Định lượng

Phương pháp sắc ký lỏng (Phụ lục 5.3).
Pha động: Acetonitril – dung dịch acid acetic 0,1 % (16:84)
Dung dịch thử: cắt một lượng dược liệu thành những mảnh nhỏ (kích thước khoảng 5 mm X 5 mm), sấy ở 80 °C, dưới áp suất giảm trong 24 h rồi nghiền thành bột thô. Cân chính xác khoảng 2 g bột dược liệu vào một bình nón nút mài, thêm chính xác 100 ml methenol (TT), đậy nút, cân. Đun sôi hồi lưu 30 min, để nguội và cân lại. Bổ sung khối lượng mất đi bằng methanol (TT), lắc đều, lọc. Lấy chính xác 50 ml dịch lọc, cất thu hồi dung môi trong chân không đến gần khô. Dùng pha động để hòa tan và chuyển toàn bộ cắn vào bình định mức 10 ml, thêm pha động vừa đủ đến vạch, lắc đều, lọc qua màng lọc 0,45 µm.
Dung dịch chuẩn: Hòa tan verbascosid chuẩn trong pha động để được dung dịch có nồng độ chính xác khoảng 10 mg/ml.
Điều kiện sắc ký: Cột kích thước (25 cm X 4,6 mm), được nhồi pha tính C (5 µm).
Derector quang phổ từ ngoại đặt ở bước sóng 334 nm.
Tốc độ dòng: 0,8 ml/min.
Thể tích tiêm: 20µl.
Cách tiến hành: Tiến hành sắc ký với dung dịch chuẩn. Tính số đĩa lý thuyết của cột. Số đĩa lý thuyết của cột tính trên pic verbascosid phải không dưới 5000. Tiến hành sắc ký với dung dịch chuẩn và dung dịch thử.
Tính hàm lượng verbascosid trong được liệu dựa vào diện tích pic thu được trên sắc ký đồ của dung dịch thử, dung dịch chuẩn, hàm lượng C29H36O15 trong verbaseosid chuẩn. Dược liệu phải chứa không dưới 0,02 % verbascosíd (C79H36O15) tính theo dược liệu khô kiệt.

Thông tin khác

• Độ ẩm: nan
• Bảo quản: nan

VI. Dược điển Hồng kong

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VII. Y dược học cổ truyền

Thục địa

Tên vị thuốc: Thục địa

Tính: Cam

Vị: Ôn

Quy kinh: Can, Thận, Tâm

Công năng chủ trị: Tư âm, bổ huyết, ích tinh, tủy. Chủ trị: Can, thận âm hư, thắt lưng đầu gối mỏi yếu, cốt chưng, triêu nhiệt, mồ hôi trộm, di tinh, âm hư ho suyễn, háo khát, Huyết hư, đánh trống ngực hồi hộp, kinh nguyệt không đều, rong huyết, chóng mặt ù tai, mắt mờ, táo bón.

Phân loại theo thông tư: nan

Tác dụng theo y dược cổ truyền: nan

Chú ý: nan

Kiêng kỵ: Kỵ sắt. Tỳ vị hư hàn không dùng

Cấu trúc hóa học của các hoạt chất thuộc nhóm Carboxylic acids and derivatives là pyroglutamic acid (LTS0198996), pyroglutamic acid (LTS0142947), [5-(acetyloxy)-1-{[3,4,5-tris(acetyloxy)-6-[(acetyloxy)methyl]oxan-2-yl]oxy}-1h,4ah,5h,7ah-cyclopenta[c]pyran-7-yl]methyl acetate (LTS0142694), [5-(acetyloxy)-10-{[3,4,5-tris(acetyloxy)-6-[(acetyloxy)methyl]oxan-2-yl]oxy}-3,9-dioxatricyclo[4.4.0.0²,⁴]decan-2-yl]methyl acetate (LTS0212908), [5-(acetyloxy)-4a-hydroxy-1-{[3,4,5-tris(acetyloxy)-6-[(acetyloxy)methyl]oxan-2-yl]oxy}-1h,5h,7ah-cyclopenta[c]pyran-7-yl]methyl acetate (LTS0198423), succinic acid (LTS0237204), [(1s,2s,4s,5s,6r,10s)-5-(acetyloxy)-10-{[(2s,3r,4s,5r,6r)-3,4,5-tris(acetyloxy)-6-[(acetyloxy)methyl]oxan-2-yl]oxy}-3,9-dioxatricyclo[4.4.0.0²,⁴]decan-2-yl]methyl acetate (LTS0268430), [(1s,4as,5r,7ar)-5-(acetyloxy)-4a-hydroxy-1-{[(2s,3r,4s,5r,6r)-3,4,5-tris(acetyloxy)-6-[(acetyloxy)methyl]oxan-2-yl]oxy}-1h,5h,7ah-cyclopenta[c]pyran-7-yl]methyl acetate (LTS0079902), [(1s,4ar,5s,7as)-5-(acetyloxy)-1-{[(2s,3r,4s,5r,6r)-3,4,5-tris(acetyloxy)-6-[(acetyloxy)methyl]oxan-2-yl]oxy}-1h,4ah,5h,7ah-cyclopenta[c]pyran-7-yl]methyl acetate (LTS0087220), (2r)-5-hydroxy-3,4-dihydro-2h-pyrrole-2-carboxylic acid (LTS0274323).

Cấu trúc hóa học của các hoạt chất thuộc nhóm Cinnamic acids and derivatives là 5-hydroxy-2-(hydroxymethyl)-6-(2-phenylethoxy)-4-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-3-yl (2z)-3-(3,4-dihydroxyphenyl)prop-2-enoate (LTS0218770), (2r,3r,4r,5r,6r)-6-[2-(2,3-dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-{[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-3-yl (2e)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate (LTS0105837), 5-hydroxy-6-[2-(3-hydroxy-4-methoxyphenyl)ethoxy]-2-(hydroxymethyl)-4-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-3-yl 3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate (LTS0108163), (2r,3r,4r,5r,6r)-6-[2-(2,3-dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-{[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-3-yl (2e)-3-(3,4-dihydroxyphenyl)prop-2-enoate (LTS0079193), 5-hydroxy-6-[2-(2-hydroxy-3-methoxyphenyl)ethoxy]-2-(hydroxymethyl)-4-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-3-yl 3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate (LTS0025158), (3r,4r,6r)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-{[(2s,3s,5r)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-3-yl (2e)-3-(3,4-dihydroxyphenyl)prop-2-enoate (LTS0063526), 6-[2-(2,3-dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-3-yl 3-(3,4-dihydroxyphenyl)prop-2-enoate (LTS0185234), verbascoside (LTS0168159), {6-[2-(3,4-dihydroxyphenyl)ethoxy]-3,5-dihydroxy-4-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-2-yl}methyl 3-(3,4-dihydroxyphenyl)prop-2-enoate (LTS0270785), (2r,3r,4r,5r,6r)-5-hydroxy-2-(hydroxymethyl)-6-(2-phenylethoxy)-4-{[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-3-yl (2e)-3-(3,4-dihydroxyphenyl)prop-2-enoate (LTS0172281), (2r,3r,4r,5r,6r)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-{[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-3-yl (2e)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate (LTS0138388), (2r,3r,4r,5r,6r)-5-hydroxy-6-[2-(2-hydroxy-3-methoxyphenyl)ethoxy]-2-(hydroxymethyl)-4-{[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-3-yl (2e)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate (LTS0262407), (2r,3r,4r,5r,6r)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-{[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-3-yl (2e)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoate (LTS0218569), (2r,3r,4r,5r,6r)-5-hydroxy-6-[2-(2-hydroxy-3-methoxyphenyl)ethoxy]-2-(hydroxymethyl)-4-{[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-3-yl (2e)-3-(3,4-dihydroxyphenyl)prop-2-enoate (LTS0232481), 6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-3-yl 3-(3,4-dihydroxyphenyl)prop-2-enoate (LTS0050472), 6-[2-(3,4-dihydroxyphenyl)ethoxy]-4,5-dihydroxy-2-{[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]methyl}oxan-3-yl 3-(3,4-dihydroxyphenyl)prop-2-enoate (LTS0048324), 6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-3-yl 3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate (LTS0063413), 6-[2-(2,3-dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-3-yl 3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate (LTS0251859), 5-hydroxy-6-[2-(3-hydroxy-4-methoxyphenyl)ethoxy]-2-(hydroxymethyl)-4-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-3-yl 3-(3,4-dihydroxyphenyl)prop-2-enoate (LTS0253347), 5-hydroxy-2-(hydroxymethyl)-6-(2-phenylethoxy)-4-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-3-yl 3-(3,4-dihydroxyphenyl)prop-2-enoate (LTS0250477), (2r,3r,4s,5r,6r)-5-(acetyloxy)-6-[2-(2,3-dihydroxyphenyl)ethoxy]-2-(hydroxymethyl)-4-{[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-3-yl (2e)-3-(3,4-dihydroxyphenyl)prop-2-enoate (LTS0038293), isoacteoside (LTS0012202), 5-(acetyloxy)-6-[2-(2,3-dihydroxyphenyl)ethoxy]-2-(hydroxymethyl)-4-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-3-yl 3-(3,4-dihydroxyphenyl)prop-2-enoate (LTS0008084), forsythiaside (LTS0012885), (2r,3r,4r,5r,6r)-5-hydroxy-6-[2-(3-hydroxy-4-methoxyphenyl)ethoxy]-2-(hydroxymethyl)-4-{[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-3-yl (2e)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate (LTS0105864), plantamajoside (LTS0032137), 5-hydroxy-6-[2-(2-hydroxy-3-methoxyphenyl)ethoxy]-2-(hydroxymethyl)-4-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-3-yl 3-(3,4-dihydroxyphenyl)prop-2-enoate (LTS0037442), 6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-3-yl 3-(3,4-dihydroxyphenyl)prop-2-enoate (LTS0255997).

Cấu trúc hóa học của các hoạt chất thuộc nhóm Diazines là pirod (LTS0008205).

Cấu trúc hóa học của các hoạt chất thuộc nhóm Dihydrofurans là 2-ethyl-5-hydroxy-3h-furan-2-carbaldehyde (LTS0151924).

Cấu trúc hóa học của các hoạt chất thuộc nhóm Epoxides là 2-methyl-2-(5-methylhexa-1,4-dien-3-yl)oxirane (LTS0023800).

Cấu trúc hóa học của các hoạt chất thuộc nhóm Fatty Acyls là 2,6,6-trimethyl-3-{[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}cyclohex-1-ene-1-carboxylic acid (LTS0121625), manninotriose (LTS0015358), (4r,5s,6r,7r)-4,5,6,7,8-pentahydroxy(1-²h₁)octan-3-one (LTS0180168), (3r)-2,6,6-trimethyl-3-{[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}cyclohex-1-ene-1-carboxylic acid (LTS0113165), 2,6,6-trimethyl-3-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}cyclohex-1-ene-1-carboxylic acid (LTS0053576), (2r,3r,4r,5r)-1,2,5-trihydroxy-6-oxo-4-{[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}hexan-3-yl (2e)-3-(3,4-dihydroxyphenyl)prop-2-enoate (LTS0248847), (4r)-2,6,6-trimethyl-4-{[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}cyclohex-1-ene-1-carboxylic acid (LTS0010484).

Cấu trúc hóa học của các hoạt chất thuộc nhóm Furans là 5-hydroxy-3-methylfuran-2-carboxylic acid (LTS0143935), 5-hydroxymethyl-2-furoic acid (LTS0243344).

Cấu trúc hóa học của các hoạt chất thuộc nhóm Heteroaromatic compounds là 6-(2-hydroxyethyl)-4h,5h,6h-cyclopenta[c]furan-4,5-diol (LTS0138180), (4r,5s,6r)-6-(2-hydroxyethyl)-4h,5h,6h-cyclopenta[c]furan-4,5-diol (LTS0038325).

Cấu trúc hóa học của các hoạt chất thuộc nhóm Hydroxy acids and derivatives là (-)-malic acid (LTS0128885).

Cấu trúc hóa học của các hoạt chất thuộc nhóm Indoles and derivatives là n-[2-(5-methoxy-1h-indol-3-yl)ethyl]ethanimidic acid (LTS0219322).

Cấu trúc hóa học của các hoạt chất thuộc nhóm Lactones là (3as,4s,6as)-4-hydroxy-6,6a-bis(hydroxymethyl)-3h,3ah,4h-cyclopenta[b]furan-2-one (LTS0095477), (3as,4r,6as)-4-hydroxy-6,6a-bis(hydroxymethyl)-3h,3ah,4h-cyclopenta[b]furan-2-one (LTS0242261), 4-hydroxy-6,6a-bis(hydroxymethyl)-3h,3ah,4h-cyclopenta[b]furan-2-one (LTS0116516).

Cấu trúc hóa học của các hoạt chất thuộc nhóm Naphthopyrans là columbin (LTS0018361).

Cấu trúc hóa học của các hoạt chất thuộc nhóm Organonitrogen compounds là sphingosine (LTS0151451).

Cấu trúc hóa học của các hoạt chất thuộc nhóm Organooxygen compounds là 5-hydroxy-6-[2-(4-hydroxy-3-methoxyphenyl)ethoxy]-2-({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)-4-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-3-yl 3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate (LTS0049733), (2r)-2-{[(1r,2s,6s)-5-hydroxy-2-(hydroxymethyl)-3,9-dioxatricyclo[4.4.0.0²,⁴]dec-7-en-10-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol (LTS0137228), jionoside b1 (LTS0058842), (2r,3r,4r,5r,6r)-5-hydroxy-6-[2-(4-hydroxy-3-methoxyphenyl)ethoxy]-2-({[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)-4-{[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-3-yl (2e)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate (LTS0132286), (2s,3r,4s,5s,6r)-2-{[(1r,5r,6s,7r,8s,9s)-5-chloro-4,6-dihydroxy-2,10-dioxatricyclo[5.3.1.0⁴,⁸]undecan-9-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol (LTS0241598), purpureaside c (LTS0241510), verbascose (LTS0097780), (2r)-2-[(2s,5r)-5-ethenyl-5-methyloxolan-2-yl]-1-(4-methylfuran-2-yl)propan-1-one (LTS0212364), (2r,3r,4r,5r,6r)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-4-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-2-({[(2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}methyl)oxan-3-yl (2e)-3-(3,4-dihydroxyphenyl)prop-2-enoate (LTS0053948), 2-({2-[2-(3,4-dihydroxyphenyl)ethoxy]-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl}oxy)-6-methyloxane-3,4,5-triol (LTS0074351), (2r,3r,4r,5r,6r)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-({[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)-4-{[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-3-yl (2z)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate (LTS0211020), (2s,3s,4s,5s,6r)-2-{[(1r,4s,5r,6s,7r,8s,9s)-5-chloro-4,6-dihydroxy-2,10-dioxatricyclo[5.3.1.0⁴,⁸]undecan-9-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol (LTS0192055), 2-[(6-{[3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy}-3,4,5-trihydroxyoxan-2-yl)methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol (LTS0213607), 1-(4-hydroxy-3-methylphenyl)ethanone (LTS0074556), [(1s,2s,4s,5s,6r,10s)-10-{[(2s,3r,4s,5r,6r)-3,4,5-tris(acetyloxy)-6-[(acetyloxy)methyl]oxan-2-yl]oxy}-5-{[(2s,3r,4s,5s,6r)-3,4,5-tris(acetyloxy)-6-[(acetyloxy)methyl]oxan-2-yl]oxy}-3,9-dioxatricyclo[4.4.0.0²,⁴]dec-7-en-2-yl]methyl acetate (LTS0102411), (2r,3r,4s,5r,6s)-2-(hydroxymethyl)-6-{[(2r,3s,4s,5r,6s)-3,4,5-trihydroxy-6-{[(1s,2s,4s,5s,6r,10s)-5-hydroxy-2-(hydroxymethyl)-3,9-dioxatricyclo[4.4.0.0²,⁴]dec-7-en-10-yl]oxy}oxan-2-yl]methoxy}oxane-3,4,5-triol (LTS0198659), 5-hydroxy-3-methylfuran-2-carbaldehyde (LTS0113782), salidroside (LTS0093636), (3s)-3-hydroxy-2,6,6-trimethylcyclohex-1-ene-1-carboxylic acid (LTS0161408), 2-(5-ethenyl-5-methyloxolan-2-yl)-1-(4-methylfuran-2-yl)propan-1-one (LTS0204411), (+)-glucose (LTS0262158), 3-hydroxy-2,6,6-trimethylcyclohex-1-ene-1-carboxylic acid (LTS0243754), sucrose (LTS0272557), 2-({5-chloro-4,6-dihydroxy-2,10-dioxatricyclo[5.3.1.0⁴,⁸]undecan-9-yl}oxy)-6-(hydroxymethyl)oxane-3,4,5-triol (LTS0128583), polydextrose (LTS0144291), mannitol (LTS0199986), ethyl glucoside (LTS0141759), 5-hydroxy-6-[2-(3-hydroxy-4-methoxyphenyl)ethoxy]-2-({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)-4-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-3-yl 3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate (LTS0152123), galactose (LTS0171628), (2r,3r,4r,5r,6r)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-({[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)-4-{[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-3-yl (2e)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate (LTS0161126), (2s,3r,4s,5s,6r)-2-{[(1s,2s,4s,5s,6s,10s)-5-hydroxy-2-(hydroxymethyl)-3,9-dioxatricyclo[4.4.0.0²,⁴]dec-7-en-10-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol (LTS0161967), catalpol (LTS0114481), [(1s,2s,4s,5s,6r,10s)-5-(acetyloxy)-10-{[(2s,3r,4s,5r,6r)-3,4,5-tris(acetyloxy)-6-({[(2s,3r,4s,5s,6r)-3,4,5-tris(acetyloxy)-6-[(acetyloxy)methyl]oxan-2-yl]oxy}methyl)oxan-2-yl]oxy}-3,9-dioxatricyclo[4.4.0.0²,⁴]dec-7-en-2-yl]methyl acetate (LTS0101637), (2s,3r,4s,5s,6r)-2-{[(1r,4s,5r,6s,7r,8s,9s)-5-chloro-4,6-dihydroxy-2,10-dioxatricyclo[5.3.1.0⁴,⁸]undecan-9-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol (LTS0160798), (2r,3s,4s,5r,6s)-2-(hydroxymethyl)-6-{[(1s,5s,6r,10s)-2-(hydroxymethyl)-5-{[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3,9-dioxatricyclo[4.4.0.0²,⁴]dec-7-en-10-yl]oxy}oxane-3,4,5-triol (LTS0119018), hydroxymethylfurfural (LTS0233269), (2r,3r,4s,5s,6r)-2-{[(2s,3r,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy}-6-({[(2s,3s,4r,5r,6r)-3,4,5-trihydroxy-6-({[(2s,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)oxan-2-yl]oxy}methyl)oxane-3,4,5-triol (LTS0183884), 6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)-4-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-3-yl 3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate (LTS0238059), (2s,3r,4r,5s,6s)-2-(hydroxymethyl)-6-{[(1s,2r,4r,5s,6r,10s)-2-(hydroxymethyl)-10-{[(2s,3r,4r,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3,9-dioxatricyclo[4.4.0.0²,⁴]dec-7-en-5-yl]oxy}oxane-3,4,5-triol (LTS0204090), catalpol (LTS0234878), (2r,3s,4s,5r,6s)-2-(hydroxymethyl)-6-{[(1s,2s,4s,5s,6r,10s)-2-(hydroxymethyl)-5-{[(2s,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3,9-dioxatricyclo[4.4.0.0²,⁴]dec-7-en-10-yl]oxy}oxane-3,4,5-triol (LTS0215757), �-d-galactopyranoside, ethyl (LTS0028146), keto-d-fructose (LTS0241114), [5,10-bis({[3,4,5-tris(acetyloxy)-6-[(acetyloxy)methyl]oxan-2-yl]oxy})-3,9-dioxatricyclo[4.4.0.0²,⁴]dec-7-en-2-yl]methyl acetate (LTS0168863), echinacoside (LTS0002111), 6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-4-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-2-{[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]methyl}oxan-3-yl 3-(3,4-dihydroxyphenyl)prop-2-enoate (LTS0169602), 6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)-4-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-3-yl 3-(4-hydroxyphenyl)prop-2-enoate (LTS0184415), (2r,3r,4r,5r,6r)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-({[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)-4-{[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-3-yl (2e)-3-(4-hydroxyphenyl)prop-2-enoate (LTS0113086), (2r,3r,4r,5r,6r)-5-hydroxy-6-[2-(4-hydroxy-3-methoxyphenyl)ethoxy]-2-({[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)-4-{[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-3-yl (2z)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate (LTS0047666), glucose (LTS0013597), aldehydo-d-galactose (LTS0128031), (2r,3r,4s,5s)-6-({[(2s,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)oxane-2,3,4,5-tetrol (LTS0135576), (2s,3r,4s,5s,6r)-2-{[(1s,2s,4s,5s,6r,10s)-5-hydroxy-2-(hydroxymethyl)-3,9-dioxatricyclo[4.4.0.0²,⁴]decan-10-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol (LTS0001855), stachyose (LTS0062089), [5-(acetyloxy)-10-{[3,4,5-tris(acetyloxy)-6-({[3,4,5-tris(acetyloxy)-6-[(acetyloxy)methyl]oxan-2-yl]oxy}methyl)oxan-2-yl]oxy}-3,9-dioxatricyclo[4.4.0.0²,⁴]dec-7-en-2-yl]methyl acetate (LTS0029604), methyl (4ar,7as)-7-methylidene-1-[(3,4,5-trihydroxy-6-{[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]methyl}oxan-2-yl)oxy]-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-4-carboxylate (LTS0032959), (2r,3r,4s,5r,6r)-2-(hydroxymethyl)-6-{[(2r,3s,4s,5r,6s)-3,4,5-trihydroxy-6-{[(1s,2s,4s,5s,6r,10s)-5-hydroxy-2-(hydroxymethyl)-3,9-dioxatricyclo[4.4.0.0²,⁴]dec-7-en-10-yl]oxy}oxan-2-yl]methoxy}oxane-3,4,5-triol (LTS0078329), (2s,3r,4r,5r,6s)-2-{[(1s,5s,6r,10s)-5-hydroxy-2-(hydroxymethyl)-3,9-dioxatricyclo[4.4.0.0²,⁴]dec-7-en-10-yl]oxy}-6-methyloxane-3,4,5-triol (LTS0030670), raffinose (LTS0113066), 6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)-4-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-3-yl 3-(3,4-dihydroxyphenyl)prop-2-enoate (LTS0250978), d-fructopyranose (LTS0259277).

Cấu trúc hóa học của các hoạt chất thuộc nhóm Oxanes là (8s,10s)-2-(hydroxymethyl)-8,10-dimethoxy-3,9-dioxatricyclo[4.4.0.0²,⁴]decan-5-ol (LTS0216173), (1s,2s,4s,5s,6r,8s,10s)-2-(hydroxymethyl)-8,10-dimethoxy-3,9-dioxatricyclo[4.4.0.0²,⁴]decan-5-ol (LTS0034028).

Cấu trúc hóa học của các hoạt chất thuộc nhóm Oxepanes là 1-isopropyl-5-methyl-3,6,7-trioxatricyclo[3.2.2.0²,⁴]nonane (LTS0174925).

Cấu trúc hóa học của các hoạt chất thuộc nhóm Prenol lipids là 5-chloro-2,10-dioxatricyclo[5.3.1.0⁴,¹¹]undecane-4,6,9-triol (LTS0069008), (1s,3r,7s)-1,3-dimethoxy-7-methyl-hexahydro-1h-cyclopenta[c]pyran-5,7-diol (LTS0077731), (2e,4e)-5-[(1r,2r)-1,2-dihydroxy-2,6,6-trimethylcyclohexyl]-3-methylpenta-2,4-dienoic acid (LTS0106962), (1s,4s,5r,6s,7r,9s,11s)-9-methoxy-2,10-dioxatricyclo[5.3.1.0⁴,¹¹]undecane-4,5,6-triol (LTS0073781), (2s,3r,4s,5r,6r)-2-{[(2s,3r,4r,5r,6r)-2-{[(1s,4as,5r,7as)-5-hydroxy-7-(hydroxymethyl)-1-{[(2r,3r,4r,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,5h,7ah-cyclopenta[c]pyran-4a-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol (LTS0082985), 4-(1,2-dihydroxy-2,6,6-trimethylcyclohexyl)but-3-en-2-one (LTS0212694), [3,4,5-tris(acetyloxy)-6-{[5-(acetyloxy)-7-hydroxy-7-methyl-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-1-yl]oxy}oxan-2-yl]methyl acetate (LTS0072245), (2s,3r,4s,5s,6r)-2-{[(2r,3r,4s,5s,6r)-2-{[(1s,4as,5r,7ar)-5-hydroxy-7-(hydroxymethyl)-1-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,5h,7ah-cyclopenta[c]pyran-4a-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol (LTS0076965), (1s,4s,5r,6s,7r,9s,11s)-5-chloro-9-methoxy-2,10-dioxatricyclo[5.3.1.0⁴,¹¹]undecane-4,6-diol (LTS0093577), (2e,4e)-5-(1,2-dihydroxy-2,6,6-trimethylcyclohexyl)-3-methylpenta-2,4-dienoic acid (LTS0214610), (1s,4ar,5r,7s,7as)-7-hydroxy-7-methyl-1-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-5-yl 3-(4-oxo-1h-pyridin-2-yl)propanoate (LTS0092598), [(2r,3r,4s,5r,6s)-6-{[(1s,4ar,5s,7s,7as)-5-(acetyloxy)-7-hydroxy-7-methyl-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-1-yl]oxy}-3,4,5-tris(acetyloxy)oxan-2-yl]methyl acetate (LTS0082940), geniposide (LTS0099201), (1s,4s,5r,6s,7r,11s)-5-chloro-2,10-dioxatricyclo[5.3.1.0⁴,¹¹]undecane-4,6,9-triol (LTS0097864), aucubin (LTS0183892), (3e)-4-[(1r,3r,6r)-1,3-dihydroxy-2,2,6-trimethyl-6-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}cyclohexyl]but-3-en-2-one (LTS0088805), (2e,4e)-3-methyl-5-[(1r,3s,6r)-1,3,6-trihydroxy-2,2,6-trimethylcyclohexyl]penta-2,4-dienoic acid (LTS0069383), (3e)-4-[(1r,2r)-1,2-dihydroxy-2,6,6-trimethylcyclohexyl]but-3-en-2-one (LTS0070859), 7-(hydroxymethyl)-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,7ah-cyclopenta[c]pyran-4-carboxylic acid (LTS0040826), (1s,4as,5r,7s,7as)-7-hydroxy-7-methyl-1-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-5-yl (2e)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate (LTS0178182), (1s,4ar,5r,7s,7as)-7-hydroxy-7-methyl-1-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-5-yl (2e)-3-phenylprop-2-enoate (LTS0051914), (1r,4s,5r,6s,7r,11s)-5-chloro-2,10-dioxatricyclo[5.3.1.0⁴,¹¹]undecane-4,6-diol (LTS0087753), (2s,3r,4s,5s,6r)-2-{[(1s,4as,5r,7ar)-4a,5-dihydroxy-7-(hydroxymethyl)-1h,5h,7ah-cyclopenta[c]pyran-1-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol (LTS0045361), [5-(acetyloxy)-1,4a-bis({[3,4,5-tris(acetyloxy)-6-[(acetyloxy)methyl]oxan-2-yl]oxy})-1h,5h,7ah-cyclopenta[c]pyran-7-yl]methyl acetate (LTS0181480), [(1s,4as,5r,7ar)-5-(acetyloxy)-1,4a-bis({[(2s,3r,4s,5r,6r)-3,4,5-tris(acetyloxy)-6-[(acetyloxy)methyl]oxan-2-yl]oxy})-1h,5h,7ah-cyclopenta[c]pyran-7-yl]methyl acetate (LTS0195706), (3e)-4-[(1r,3s,6r)-1,3,6-trihydroxy-2,2,6-trimethylcyclohexyl]but-3-en-2-one (LTS0205859), (1s,4ar,5r,7s,7as)-7-hydroxy-7-methyl-1-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-5-yl (2e,4e)-5-[(1r,2r)-1,2-dihydroxy-2,6,6-trimethylcyclohexyl]-3-methylpenta-2,4-dienoate (LTS0150911), rehmaionoside b (LTS0176882), 2-{[2-hydroxy-2-(3-hydroxybut-1-en-1-yl)-1,3,3-trimethylcyclohexyl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol (LTS0271768), 5-[(1r,6r)-1-hydroxy-2,2,6-trimethyl-6-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}cyclohexyl]-3-methylpenta-2,4-dienoic acid (LTS0248539), (1s,4as,6s,7s,7as)-6-hydroxy-7-methyl-1-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7h,7ah-cyclopenta[c]pyran-4-carboxylic acid (LTS0260312), methyl 7-(hydroxymethyl)-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,7ah-cyclopenta[c]pyran-4-carboxylate (LTS0134702), 3-methyl-5-(1,3,6-trihydroxy-2,2,6-trimethylcyclohexyl)penta-2,4-dienoic acid (LTS0144072), (4s,6s,9s)-9-methoxy-2,10-dioxatricyclo[5.3.1.0⁴,¹¹]undecane-4,5,6-triol (LTS0148165), (2r,3s,4r,5r,6s)-2-{[(1s,4as,5r,7ar)-5-hydroxy-7-(hydroxymethyl)-1h,4ah,5h,7ah-cyclopenta[c]pyran-1-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol (LTS0139904), (2s,3r,4s,5s,6r)-2-{[(1s,4ar,5r,7s,7as)-5,7-dihydroxy-7-methyl-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-1-yl]oxy}-6-({[(1r,3r,4as,5s,7r,7ar)-5,7-dihydroxy-7-methyl-1-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-hexahydro-1h-cyclopenta[c]pyran-3-yl]oxy}methyl)oxane-3,4,5-triol (LTS0143134), (2s,3r,4s,5s,6r)-2-{[(1s,4ar,5r,7s,7as)-5,7-dihydroxy-7-methyl-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-1-yl]oxy}-6-({[(1r,3s,4as,5s,7r,7ar)-5,7-dihydroxy-7-methyl-1-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-hexahydro-1h-cyclopenta[c]pyran-3-yl]oxy}methyl)oxane-3,4,5-triol (LTS0163772), (2s,3r,4s,5s,6r)-2-{[(1s,4as,5r,7ar)-5-hydroxy-7-(hydroxymethyl)-1-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,5h,7ah-cyclopenta[c]pyran-4a-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol (LTS0260659), (4s,6s,9r)-5-chloro-9-methoxy-2,10-dioxatricyclo[5.3.1.0⁴,¹¹]undecane-4,6-diol (LTS0160793), 5-chloro-2,10-dioxatricyclo[5.3.1.0⁴,¹¹]undecane-4,6-diol (LTS0164990), (1s,4s,5r,6s,7r,9r,11s)-5-chloro-9-methoxy-2,10-dioxatricyclo[5.3.1.0⁴,¹¹]undecane-4,6-diol (LTS0239948), (2r,3r,4s,5r,6r)-2-{[(1s,4ar,5r,7as)-7-hydroxy-7-methyl-1-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-5-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol (LTS0230172), 5-chloro-9-methoxy-2,10-dioxatricyclo[5.3.1.0⁴,¹¹]undecane-4,6-diol (LTS0254017), (1s,4ar,5r,7s,7as)-7-hydroxy-7-methyl-1-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-5-yl (2e,4e)-5-[(1r,6r)-1-hydroxy-2,2,6-trimethyl-6-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}cyclohexyl]-3-methylpenta-2,4-dienoate (LTS0164115), methyl (1s,4as,5r,7s,7ar)-5-hydroxy-7-methyl-1-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7h,7ah-cyclopenta[c]pyran-4-carboxylate (LTS0233229), (1s,4s,5r,6s,7r,9s,11s)-5-chloro-2,10-dioxatricyclo[5.3.1.0⁴,¹¹]undecane-4,6,9-triol (LTS0169131), phorbol (LTS0183626), geniposidic acid (LTS0051067), 5-hydroxy-7-methyl-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-7-yl acetate (LTS0213072), 5,7-dihydroxy-7-methyl-hexahydrocyclopenta[c]pyran-3-one (LTS0196200), (4ar,5r,7s,7ar)-5,7-dihydroxy-7-methyl-hexahydrocyclopenta[c]pyran-3-one (LTS0034887), 2,10-dioxatricyclo[5.3.1.0⁴,¹¹]undecane-4,5,6-triol (LTS0203602), 2-({5,7-dihydroxy-7-methyl-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-1-yl}oxy)-6-(hydroxymethyl)oxane-3,4,5-triol (LTS0221528), (2s,3r,4s,5s,6r)-2-{[(2s,3r,4s,5s,6r)-2-{[(1s,4as,5r,7ar)-5-hydroxy-7-(hydroxymethyl)-1-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,5h,7ah-cyclopenta[c]pyran-4a-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol (LTS0052321), (1r,4s,5r,6s,7r,11s)-2,10-dioxatricyclo[5.3.1.0⁴,¹¹]undecane-4,5,6-triol (LTS0217778), (1s,4s,5s,6s,7r,9s,11s)-5-chloro-9-methoxy-2,10-dioxatricyclo[5.3.1.0⁴,¹¹]undecane-4,6-diol (LTS0215574), rehmaionoside c (LTS0238931), methyl (4ar,7as)-7-(hydroxymethyl)-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,7ah-cyclopenta[c]pyran-4-carboxylate (LTS0021217), (2s,3r,4s,5s,6r)-2-{[(1r,2r,4r)-2,4-dihydroxy-2-[(1e,3s)-3-hydroxybut-1-en-1-yl]-1,3,3-trimethylcyclohexyl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol (LTS0178257), 4-(1-hydroxy-2,2,6-trimethyl-6-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}cyclohexyl)but-3-en-2-one (LTS0204057), (4s,6s,9s)-5-chloro-9-methoxy-2,10-dioxatricyclo[5.3.1.0⁴,¹¹]undecane-4,6-diol (LTS0161573), (2s,3r,4s,5s,6r)-2-{[(1s,4ar,5r,7s,7as)-5,7-dihydroxy-7-methyl-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-1-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol (LTS0242528), leonuridine (LTS0243898), rehmaionoside a (LTS0045245), 2-[(4,5-dihydroxy-2-{[5-hydroxy-7-(hydroxymethyl)-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,5h,7ah-cyclopenta[c]pyran-4a-yl]oxy}-6-(hydroxymethyl)oxan-3-yl)oxy]-6-(hydroxymethyl)oxane-3,4,5-triol (LTS0007542), (2s,3r,4s,5s,6r)-2-{[(1r,2r,4r)-2,4-dihydroxy-2-[(3s)-3-hydroxybut-1-en-1-yl]-1,3,3-trimethylcyclohexyl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol (LTS0044100), (1s,3r,4ar,5r,7s,7as)-1,3-dimethoxy-7-methyl-hexahydro-1h-cyclopenta[c]pyran-5,7-diol (LTS0043610), (2r,3r,4s,5r,6r)-2-{[(1s,4ar,5r,7s,7as)-5-hydroxy-7-methyl-1-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-7-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol (LTS0003754), [(2r,3s,4s,5r,6r)-6-{[(1s,4ar,5s,7s,7as)-5-(acetyloxy)-7-methyl-1-{[(2s,3r,4s,5r,6r)-3,4,5-tris(acetyloxy)-6-[(acetyloxy)methyl]oxan-2-yl]oxy}-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-7-yl]oxy}-3,4,5-tris(acetyloxy)oxan-2-yl]methyl acetate (LTS0058016), (1s,4ar,5r,7s,7as)-5-hydroxy-7-methyl-1-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-7-yl acetate (LTS0129480), (1s,4ar,5r,7s,7as)-7-hydroxy-7-methyl-1-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-5-yl (2e)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate (LTS0003164), 7-hydroxy-7-methyl-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-5-yl 3-methyl-5-(1,3,6-trihydroxy-2,2,6-trimethylcyclohexyl)penta-2,4-dienoate (LTS0271916), (1s,4ar,5r,7s,7as)-7-hydroxy-7-methyl-1-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-5-yl (2e)-3-[(2r,3s)-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1-benzofuran-5-yl]prop-2-enoate (LTS0063518), (2s,3r,4s,5s,6r)-2-{[(1s,4ar,7s,7as)-5,7-dihydroxy-7-methyl-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-1-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol (LTS0007100), (2e,4e)-5-[(1r,6r)-1-hydroxy-2,2,6-trimethyl-6-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}cyclohexyl]-3-methylpenta-2,4-dienoic acid (LTS0273609), (1s,4ar,5r,7s,7as)-7-hydroxy-7-methyl-1-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-5-yl (2e,4e)-3-methyl-5-[(1r,3s,6r)-1,3,6-trihydroxy-2,2,6-trimethylcyclohexyl]penta-2,4-dienoate (LTS0022341), (1s,4ar,5r,7s,7as)-7-hydroxy-7-methyl-1-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-5-yl (2e,4e)-3-methyl-5-[(1r,2r,4s)-1,2,4-trihydroxy-2,6,6-trimethylcyclohexyl]penta-2,4-dienoate (LTS0000218), [3,4,5-tris(acetyloxy)-6-{[5-(acetyloxy)-7-methyl-7-{[3,4,5-tris(acetyloxy)-6-[(acetyloxy)methyl]oxan-2-yl]oxy}-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-1-yl]oxy}oxan-2-yl]methyl acetate (LTS0017059), (2s,3r,4s,5s,6r)-2-{[(1r,2r,4s)-2,4-dihydroxy-2-(5-hydroxy-3-methylpenta-1,3-dien-1-yl)-1,3,3-trimethylcyclohexyl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol (LTS0013012), (2r)-2-{[(2r)-2-{[(4as,7as)-5-hydroxy-7-(hydroxymethyl)-1-{[(2r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,5h,7ah-cyclopenta[c]pyran-4a-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol (LTS0011573), 2-{[5-hydroxy-7-(hydroxymethyl)-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,5h,7ah-cyclopenta[c]pyran-4a-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol (LTS0005469), 4-(1,3,6-trihydroxy-2,2,6-trimethylcyclohexyl)but-3-en-2-one (LTS0000166), aucubin (LTS0010822), 5-(1,2-dihydroxy-2,6,6-trimethylcyclohexyl)-3-methylpenta-2,4-dienoic acid (LTS0236538), (2s,3s,4s,5s,6s)-2-{[(2s,3s,4s,5s,6r)-2-{[(1s,4ar,5r,7ar)-5-hydroxy-7-(hydroxymethyl)-1-{[(2r,3s,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,5h,7ah-cyclopenta[c]pyran-4a-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol (LTS0232202), 9-methoxy-2,10-dioxatricyclo[5.3.1.0⁴,¹¹]undecane-4,5,6-triol (LTS0003536), 7-hydroxy-7-methyl-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-5-yl 3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate (LTS0000398), (2s,3r,4s,5s,6r)-2-{[(1r,2r)-2-hydroxy-2-[(1e)-3-hydroxybut-1-en-1-yl]-1,3,3-trimethylcyclohexyl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol (LTS0115958), (2r,3s,4r,5r,6s)-2-{[(1s,4as,5r,7ar)-5-hydroxy-7-(hydroxymethyl)-1-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,5h,7ah-cyclopenta[c]pyran-4a-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol (LTS0257102), (1s,4ar,5r,7s,7as)-7-hydroxy-7-methyl-1-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-5-yl (2e,4e)-3-methyl-5-[(1r,2r,3r)-1,2,3-trihydroxy-2,6,6-trimethylcyclohexyl]penta-2,4-dienoate (LTS0118863), (1s,4ar,7s,7as)-5-hydroxy-7-methyl-1-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-7-yl acetate (LTS0037296), (2s,3r,4s,5s,6r)-2-{[(1r,2r,4s)-2,4-dihydroxy-2-[(1e,3e)-5-hydroxy-3-methylpenta-1,3-dien-1-yl]-1,3,3-trimethylcyclohexyl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol (LTS0249083).

Cấu trúc hóa học của các hoạt chất thuộc nhóm Pyrans là 2,4-dimethoxy-2-methyl-6h-pyran-3-one (LTS0240978), (2r)-2,4-dimethoxy-2-methyl-6h-pyran-3-one (LTS0251691).

Cấu trúc hóa học của các hoạt chất thuộc nhóm Pyrimidine nucleosides là uridine (LTS0220125).

Cấu trúc hóa học của các hoạt chất thuộc nhóm Sphingolipids là 2-hydroxy-n-[(2s,3r,4e,8e)-3-hydroxy-1-{[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}octadeca-4,8-dien-2-yl]hexadecanimidic acid (LTS0063665).

Cấu trúc hóa học của các hoạt chất thuộc nhóm Steroids and steroid derivatives là prednisolone acetate (LTS0134274).

Cấu trúc hóa học của các hoạt chất thuộc nhóm Tannins là (1s,4ar,5r,7s,7as)-7-hydroxy-7-methyl-1-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-5-yl 3-methoxy-4-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}benzoate (LTS0059970), (1s,4ar,5r,7s,7as)-7-hydroxy-7-methyl-1-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-5-yl 4-hydroxy-3-methoxybenzoate (LTS0028750), (1s,4ar,5r,7s,7as)-7-hydroxy-7-methyl-1-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-5-yl 3,5-dimethoxy-4-{[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}benzoate (LTS0205422), (1s,4ar,5r,7s,7as)-7-hydroxy-7-methyl-1-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-5-yl 3-methoxy-4-{[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}benzoate (LTS0222824), 7-hydroxy-7-methyl-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7ah-cyclopenta[c]pyran-5-yl 3-methoxy-4-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]benzoate (LTS0253551).